Situated in south-eastern Turkey, Zeugma is an important Hellenistic and Roman city located at the river Euphrates and established by the commander Seleucus Nicator around 300 BC. After annexation into the Kingdom of Commagene, Zeugma became one of the most important cities of the Kingdom in the 1st century BC and a major eastern frontier city on the Euphrates in the Roman Imperial period. Today the site is partly overflowed by a barrier lake. Recent works have focused on the city’s main sanctuary on Belkıs Tepe, as well as other significant sectors of the town. The excavations have unearthed new pieces from the cult statues, which raised further questions regarding the interpretation of the chief deities of the sanctuary as well as the ruler cult in the city. Meanwhile, research concentrated on the dwellings from the Roman Imperial period shed new light on the character and uses of the domestic sphere, and provided clues for interpreting mosaics and wall paintings. Finally, geophysical prospections carried out at the city walls and the Roman military garrison, compounded by research on the necropoleis, have revealed important results for the urban fabric of the city.